PAPPA2

Pappalysin-2 is a protein that in humans is encoded by the PAPPA2 gene.

References

Further reading

Pregnancy-associated plasma protein A

Pappalysin-1 also known as pregnancy-associated plasma protein A is a protein that in humans is encoded by the PAPPA gene. Pappalysin-1 is used in screening tests for Down syndrome.

Function

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses (fetuses with an abnormal number of chromosomes). For example, low PAPPA may be seen in prenatal screening for Down syndrome. Low levels may alternatively predict issues with the placenta, resulting in adverse complications such as intrauterine growth restriction, preeclampsia, placental abruption, premature birth, or fetal death.

Interactions

Pregnancy-associated plasma protein A has been shown to interact with Major basic protein.